New Geometric Data Structures for Collision Detection

We present new geometric data structures for collision detection and more, including: Inner Sphere Trees - the first data structure to compute the peneration volume efficiently. Protosphere - an new algorithm to compute space filling sphere packings for arbitrary objects. Kinetic AABBs - a bounding volume hierarchy that is optimal in the number of updates when the objects deform. Kinetic Separation-List - an algorithm that is able to perform continuous collision detection for complex deformable objects in real-time. Moreover, we present applications of these new approaches to hand animation, real-time collision avoidance in dynamic environments for robots and haptic rendering, including a user study that exploits the influence of the degrees of freedom in complex haptic interactions. Last but not least, we present a new benchmarking suite for both, peformance and quality benchmarks, and a theoretic analysis of the running-time of bounding volume-based collision detection algorithms

Genetic control of the operculum and capsule morphology of Eucalyptus globulus

The petaline operculum that covers the inner whorls until anthesis and the woody capsule that develops after fertilization are reproductive structures of eucalypts that protect the flower and seeds. Although they are distinct organs, they both develop from flower buds and this common ontogeny suggests shared genetic control. In Eucalyptus globulus their morphology is variable and we aimed to identify the quantitative trait loci (QTL) underlying this variation and determine whether there is common genetic control of these ecologically and taxonomically important reproductive structures.EEA Bella VistaFil: Hernández, Mariano Agustín. University of Tasmania. School of Natural Sciences; Australia.Fil: Hernández, Mariano Agustín. University of Tasmania. ARC Training Centre for Forest Value; Australia.Fil: Hernández, Mariano Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bella Vista; Argentina.Fil: Butler, Jakob B. University of Tasmania. School of Natural Sciences; Australia.Fil: Ammitzboll, Hans. University of Tasmania. School of Natural Sciences; Australia.Fil: Ammitzboll, Hans. University of Tasmania. ARC Training Centre for Forest Value; Australia.Fil: Weller, James L. University of Tasmania. School of Natural Sciences; Australia.Fil: Weller, James L. Australian Research Council Centre of Excellence for Plant Success in Nature and Agriculture; Australia.Fil: Vaillancourt, René E. University of Tasmania. School of Natural Sciences; Australia.Fil: Vaillancourt, René E. University of Tasmania. ARC Training Centre for Forest Value; Australia.Fil: Potts, Brad M. University of Tasmania. School of Natural Sciences; Australia.Fil: Potts, Brad M. University of Tasmania. ARC Training Centre for Forest Value; Australia

Metabolic Cleavage and Translocation Efficiency of Selected Cell Penetrating Peptides: A Comparative Study with Epithelial Cell Cultures

We investigated the metabolic stability of four cell penetrating peptides (CPPs), namely SAP, hCT(9-32)-br, [Pα] and [Pβ], when in contact with either subconfluent HeLa, confluent MDCK or Calu-3 epithelial cell cultures. Additionally, through analysis of their cellular translocation efficiency, we evaluated possible relations between metabolic stability and translocation efficiency. Metabolic degradation kinetics and resulting metabolites were assessed using RP-HPLC and MALDI-TOF mass spectrometry. Translocation efficiencies were determined using fluorescence-activated cell sorting (FACS) and confocal laser scanning microscopy (CLSM). Between HeLa, MDCK and Calu-3 we found the levels of proteolytic activities to be highly variable. However, for each peptide, the individual degradation patterns were quite similar. The metabolic stability of the investigated CPPs was in the order of CF-SAP = CF-hCT(9-32)-br > [Pβ]−IAF > [Pα] and we identified specific cleavage sites for each of the four peptides. Throughout, we observed higher translocation efficiencies into HeLa cells as compared to MDCK and Calu-3, corresponding to the lower state of differentiation of HeLa cell cultures. No direct relation between metabolic stability and translocation efficiency was found, indicating that metabolic stability in general is not a main limiting factor for efficient cellular translocation. Nevertheless, translocation of individual CPPs may be improved by structural modifications aiming at increased metabolic stabilit

Numerical approach to synthesizing realistic asteroid surfaces from morphological parameters

Context. The complex shape of asteroids and comets is a critical parameter in many scientific and operational studies. From the global irregular shape down to the local surface details, these topographies reflect the formation and evolutionary processes that remould the celestial body. Furthermore, these processes control how the surface will continue to evolve: from mass wasting on high slopes to spin-up due to anisotropic re-emission of thermal radiation. In addition, for space missions, the irregular coarse shape and complex landscape are a hazard to navigation, which must be accounted for in the planning phase. Aims. In this paper, we propose a novel method to synthesize physically correct 3D shape models of small celestial bodies, such as asteroids, to support the testing of a wide range of parameters in scientific and operational studies. Methods. We modeled virtual asteroid shapes using non-uniform sphere packings to represent the coarse shape, define an implicit surface, and then synthesize high-resolution topography with user-defined, locally controlled spot noise models. This effectively replaces the random noise model (e.g., Perlin noise) used in traditional approaches and allows us to construct a morphology based on actual physical shapes of the most common features observed on asteroids and comets. As an example of such a feature, we propose several kernel functions to add virtual craters to the coarse shape of the asteroid, of which the spatial distribution is controlled by typical crater production functions (e.g., a power law). Results. We demonstrate how this technique can be used to generate a variety of asteroid shapes and topographies using different cratering parameters and distributions. We apply our technique to artificially increase the resolution of existing models of the Didymos-Dimorphos system, the target of the Double Asteroid Redirection Test, and Hera missions. We show that our approach generates models that are suitable for typical analysis relying on detailed asteroid shapes, as well as operational scenarios for space missions. The meshes created with our algorithm can be directly used with existing visualization software and operations or science pipelines to generate data suitable for mission planning and to validate data analysis techniques

Messen mentaler Auslastung in einer VR-Umgebung basierend auf Eyetrackingdaten

Hainke C, Pfeiffer T. Messen mentaler Auslastung in einer VR-Umgebung basierend auf Eyetrackingdaten. In: Dörner R, Kruse R, Mohler B, Weller R, eds. Virtuelle und Erweiterte Realität - 14. Workshop der GI-Fachgruppe VR/AR. Berichte aus der Informatik. Aachen: Shaker Verlag; 2017: 43-54.Ein aufmerksamer Assistent liefert proaktiv relevante Informationen immer genau zum richtigen Zeitpunkt. Er muss dafür über den aktuellen Handlungskontext und das erforderliche Domänenwissen verfügen und in der Lage sein, die aktuelle kognitive Situation des Nutzers gut einschätzen zu können. Die vorliegende Arbeit untersucht unter Einsatz eines Head-Mounted-Displays (HMDs) mit integriertem Eyetracker, ob die kognitive Belastung über die Echtzeitanalyse der Pupillengröße verlässlich geschätzt werden kann. Es wird gezeigt, dass es in einer VR-Umgebung möglich ist, mit diesen Mitteln die Pupillengröße mit der kognitiven Belastung in Zusammenhang zu setzen, da sie sich bei erhöhter Belastung vergrößert. Ausgenutzt wird dabei, dass die Helligkeit der Umgebung primär durch den Inhalt auf dem HMD-Display bestimmt wird und sich diese damit zur Laufzeit leicht bestimmen lässt

A cadaver‑based biomechanical model of acetabulum reaming for surgical virtual reality training simulators

Total hip arthroplasty (THA) is a highly successful surgical procedure, but complications remain, including aseptic loosening, early dislocation and misalignment. These may partly be related to lacking training opportunities for novices or those performing THA less frequently. A standardized training setting with realistic haptic feedback for THA does not exist to date. Virtual Reality (VR) may help establish THA training scenarios under standardized settings, morphology and material properties. This work summarizes the development and acquisition of mechanical properties on hip reaming, resulting in a tissue-based material model of the acetabulum for force feedback VR hip reaming simulators. With the given forces and torques occurring during the reaming, Cubic Hermite Spline interpolation seemed the most suitable approach to represent the nonlinear forcedisplacement behavior of the acetabular tissues over Cubic Splines. Further, Cubic Hermite Splines allowed for a rapid force feedback computation below the 1 ms hallmark. The Cubic Hermite Spline material model was implemented using a three-dimensional-sphere packing model. The resulting forces were delivered via a human–machine-interaction certified KUKA iiwa robotic arm used as a force feedback device. Consequently, this novel approach presents a concept to obtain mechanical data from high-force surgical interventions as baseline data for material models and biomechanical considerations; this will allow THA surgeons to train with a variety of machining hardness levels of acetabula for haptic VR acetabulum reaming

A Novel Role for CD55 in Granulocyte Homeostasis and Anti-Bacterial Host Defense

Background: In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes. Methodology/Results: Here,wedemonstratethatCD55-deficientmicedisplay a comparable phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen. This granulocytosis was independent of increased complement activity. Augmented numbers of Gr-1-positive cells in cell cycle in the bone marrow indicated a higher granulopoietic activity in mice lacking either CD55 or CD97. Concomitant with the increase in blood granulocyte numbers, Cd55-/mice challenged with the respiratory pathogen Streptococcus pneumoniae developed less bacteremia and died later after infection. Conclusions: Collectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionall